Type I hypersensitivity is mediated by which immunoglobulin?

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Multiple Choice

Type I hypersensitivity is mediated by which immunoglobulin?

Explanation:
Type I hypersensitivity is driven by IgE. IgE binds to high-affinity receptors on mast cells and basophils, arming them to release mediators when an allergen is encountered. Upon allergen cross-linking, these cells degranulate and release histamine, leukotrienes, and other chemicals, causing rapid symptoms like itching, hives, swelling, bronchoconstriction, and sometimes anaphylaxis. Other immunoglobulins are involved in different hypersensitivity types (IgG and IgM in antibody-mediated and immune complex reactions; IgA in mucosal defense), but IgE is the mediator specific to this immediate allergic reaction.

Type I hypersensitivity is driven by IgE. IgE binds to high-affinity receptors on mast cells and basophils, arming them to release mediators when an allergen is encountered. Upon allergen cross-linking, these cells degranulate and release histamine, leukotrienes, and other chemicals, causing rapid symptoms like itching, hives, swelling, bronchoconstriction, and sometimes anaphylaxis. Other immunoglobulins are involved in different hypersensitivity types (IgG and IgM in antibody-mediated and immune complex reactions; IgA in mucosal defense), but IgE is the mediator specific to this immediate allergic reaction.

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