The classical complement activation pathway is initiated by which component?

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Multiple Choice

The classical complement activation pathway is initiated by which component?

Explanation:
Initiation of the classical pathway is triggered by the C1 complex. C1q binds to the Fc region of antibodies (usually IgM or IgG) that are attached to an antigen, which activates the associated proteases C1r and C1s. Activated C1s then cleaves C4 and C2 to form the C4b2a C3 convertase, kicking off the cascade that leads to C3 activation and downstream effects like opsonization, inflammation, and the membrane attack complex. The other components listed are involved later in the cascade or in the terminal steps (C3 is a substrate that gets cleaved to propagate the response; C9 is part of the membrane attack complex; C5a is an inflammatory mediator produced downstream).

Initiation of the classical pathway is triggered by the C1 complex. C1q binds to the Fc region of antibodies (usually IgM or IgG) that are attached to an antigen, which activates the associated proteases C1r and C1s. Activated C1s then cleaves C4 and C2 to form the C4b2a C3 convertase, kicking off the cascade that leads to C3 activation and downstream effects like opsonization, inflammation, and the membrane attack complex. The other components listed are involved later in the cascade or in the terminal steps (C3 is a substrate that gets cleaved to propagate the response; C9 is part of the membrane attack complex; C5a is an inflammatory mediator produced downstream).

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